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RecBCD enzyme switches lead motor subunits in response to χ-recognition

RecBCD is a DNA helicase comprising two motor subunits, RecB and RecD. Recognition of the recombination hotspot, χ, causes RecBCD to pause and reduce translocation speed. To understand this control of translocation, we used single-molecule visualization to compare RecBCD to the RecBCD(K177Q) mutant...

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Autors principals: Spies, Maria, Amitani, Ichiro, Baskin, Ronald J., Kowalczykowski, Stephen C.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151923/
https://ncbi.nlm.nih.gov/pubmed/18022364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.09.023
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