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Release of dendritic cells from cognate CD4(+) T-cell recognition results in impaired peripheral tolerance and fatal cytotoxic T-cell mediated autoimmunity
Resting dendritic cells (DCs) induce tolerance of peripheral T cells that have escaped thymic negative selection and thus contribute significantly to protection against autoimmunity. We recently showed that CD4(+)Foxp3(+) regulatory T cells (Tregs) are important for maintaining the steady-state phen...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384145/ https://ncbi.nlm.nih.gov/pubmed/22615402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110620109 |
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