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Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

Lack of immunological tolerance against self-antigens results in autoimmune disorders. During onset of autoimmunity, dendritic cells (DCs) are thought to be critical for priming of self-reactive T cells that have escaped tolerance induction. However, because DCs can also induce T cell tolerance, it...

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書誌詳細
主要な著者: Ohnmacht, Caspar, Pullner, Andrea, King, Susan B.S., Drexler, Ingo, Meier, Stefanie, Brocker, Thomas, Voehringer, David
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699126/
https://ncbi.nlm.nih.gov/pubmed/19237601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082394
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