Complement Inhibition Promotes Endogenous Neurogenesis and Sustained Anti-Inflammatory Neuroprotection following Reperfused Stroke

BACKGROUND AND PURPOSE: The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent reports also implicat...

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Detalhes bibliográficos
Main Authors: Ducruet, Andrew F., Zacharia, Brad E., Sosunov, Sergey A., Gigante, Paul R., Yeh, Mason L., Gorski, Justin W., Otten, Marc L., Hwang, Richard Y., DeRosa, Peter A., Hickman, Zachary L., Sergot, Paulina, Connolly, E. Sander
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383680/
https://ncbi.nlm.nih.gov/pubmed/22761695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038664
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