Complement Inhibition Promotes Endogenous Neurogenesis and Sustained Anti-Inflammatory Neuroprotection following Reperfused Stroke

BACKGROUND AND PURPOSE: The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent reports also implicat...

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Hauptverfasser: Ducruet, Andrew F., Zacharia, Brad E., Sosunov, Sergey A., Gigante, Paul R., Yeh, Mason L., Gorski, Justin W., Otten, Marc L., Hwang, Richard Y., DeRosa, Peter A., Hickman, Zachary L., Sergot, Paulina, Connolly, E. Sander
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383680/
https://ncbi.nlm.nih.gov/pubmed/22761695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038664
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