Ebselen and congeners inhibit NADPH-oxidase 2 (Nox2)-dependent superoxide generation by interrupting the binding of regulatory subunits

NADPH-oxidases are a primary source of reactive oxygen species (ROS), which function in normal physiology and, when overproduced, in pathophysiology. Recent studies using mice deficient in Nox2 identify this isoform as a novel target against Nox2-implicated inflammatory diseases. Nox2 activation dep...

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Hlavní autoři: Smith, Susan M.E., Min, Jaeki, Ganesh, Thota, Diebold, Becky, Kawahara, Tsukasa, Zhu, Yerun, McCoy, James, Sun, Aiming, Snyder, James P., Fu, Haian, Du, Yuhong, Lewis, Iestyn, Lambeth, J. David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383625/
https://ncbi.nlm.nih.gov/pubmed/22726689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.04.015
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