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Fusing telomeres with RNF8
DNA repair activities at DNA double-strand breaks (DSBs) are under control of regulatory ubiquitylation events governed by the RNF8 and RNF168 ubiquitin-ligases. Defects in this regulatory mechanism, as with mutation of other key DNA damage-response factors, lead to genomic instability and cancer, p...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383569/ https://ncbi.nlm.nih.gov/pubmed/22555600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/nucl.19322 |
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