NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo

Drug release rate is an important factor in determining efficacy and toxicity of nanoscale drug delivery systems. However, optimization of the release rate in polymeric micellar nanoscale drug delivery systems has not been fully investigated. In this study NC-6301, a poly(ethylene glycol)-poly(aspar...

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Bibliografiske detaljer
Main Authors: Harada, Mitsunori, Iwata, Caname, Saito, Hiroyuki, Ishii, Kenta, Hayashi, Tatsuyuki, Yashiro, Masakazu, Hirakawa, Kosei, Miyazono, Kohei, Kato, Yasuki, Kano, Mitsunobu R
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2012
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383288/
https://ncbi.nlm.nih.gov/pubmed/22745540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S31247
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