Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia

We recently reported promising clinical activity for a 10-day regimen of decitabine in older AML patients; high miR-29b expression associated with clinical response. Subsequent preclinical studies with bortezomib in AML cells have shown drug-induced miR-29b up-regulation, resulting in loss of transc...

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Bibliografiske detaljer
Main Authors: Blum, William, Schwind, Sebastian, Tarighat, Somayeh S., Geyer, Susan, Eisfeld, Ann-Kathrin, Whitman, Susan, Walker, Alison, Klisovic, Rebecca, Byrd, John C., Santhanam, Ramasamy, Wang, Hongyan, Curfman, John P., Devine, Steven M., Jacob, Samson, Garr, Celia, Kefauver, Cheryl, Perrotti, Danilo, Chan, Kenneth K., Bloomfield, Clara D., Caligiuri, Michael A., Grever, Michael R., Garzon, Ramiro, Marcucci, Guido
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Clinical Trials and Observations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383015/
https://ncbi.nlm.nih.gov/pubmed/22566605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-413898
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