Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia

Patients with heparin-induced thrombocytopenia (HIT) remain at risk for recurrent thromboembolic complications despite improvements in management. HIT is caused by antibodies that preferentially recognize ultralarge complexes (ULCs) of heparin and platelet factor 4 (PF4) tetramers. We demonstrated p...

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Главные авторы: Sachais, Bruce S., Rux, Ann H., Cines, Douglas B., Yarovoi, Serge V., Garner, Lee I., Watson, Stephen P., Hinds, Jillian L., Rux, John J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2012
Предметы:
Plenary Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383011/
https://ncbi.nlm.nih.gov/pubmed/22452981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-406801
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