Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells

Natural killer (NK) cells are potent anti-viral and antitumor “first responders” endowed with natural cytotoxicity and cytokine production capabilities. To date, attempts to translate these promising biologic functions through the adoptive transfer of NK cells for the treatment of cancer have been o...

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Detalhes bibliográficos
Principais autores: Gill, Saar, Vasey, Adrianne E., De Souza, Alysha, Baker, Jeanette, Smith, Aaron T., Kohrt, Holbrook E., Florek, Mareike, Gibbs, Kenneth D., Tate, Keri, Ritchie, David S., Negrin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382935/
https://ncbi.nlm.nih.gov/pubmed/22544698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415364
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