A CpG-loaded tumor cell vaccine induces antitumor CD4(+) T cells that are effective in adoptive therapy for large and established tumors

We designed a whole tumor cell vaccine by “loading” lymphoma tumor cells with CG-enriched oligodeoxynucleotide (CpG), a ligand for the Toll-like receptor 9 (TLR9). CpG-loaded tumor cells were phagocytosed, delivering both tumor antigen(s) and the immunostimulatory CpG molecule to antigen-presenting...

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Bibliographic Details
Main Authors:	Goldstein, Matthew J., Varghese, Bindu, Brody, Joshua D., Rajapaksa, Ranjani, Kohrt, Holbrook, Czerwinski, Debra K., Levy, Shoshana, Levy, Ronald
Format:	Artigo
Language:	Inglês
Published:	American Society of Hematology 2011
Subjects:	Immunobiology
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3037739/ https://ncbi.nlm.nih.gov/pubmed/20876455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-288456
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A CpG-loaded tumor cell vaccine induces antitumor CD4(+) T cells that are effective in adoptive therapy for large and established tumors

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