Association of a functional Indoleamine 2,3-dioxygenase 2 genotype with specific immune responses

Two frequent single-nucleotide-polymorphisms (SNPs) are present in the indoleamine 2,3-dioxygenase 2 (IDO2) gene that influence its enzymatic activity. Thus, one SNP (R248W) is associated with a reduction in IDO2 catalytic activity, whereas the other SNP (Y359stop) generates a premature stop codon a...

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Autors principals: Køllgaard, Tania, Klausen, Tobias Wirenfeldt, Idorn, Manja, Holmgaard, Rikke Bæk, Straten, Per thor, Andersen, Mads Hald
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382899/
https://ncbi.nlm.nih.gov/pubmed/22754762
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