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CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection

We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8(+) T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of...

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Bibliografiske detaljer
Main Authors: Waitz, Rebecca, Fassò, Marcella, Allison, James P.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382897/
https://ncbi.nlm.nih.gov/pubmed/22754781
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