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A molecular profile of T-cell exhaustion in cancer
The first gene profiling study of cancer-specific CD8+ T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations,(1) similar as in “exhausted” T-cells in chronic infection.(2) The data suggest novel drug targets, and show that T-cell exhaustion is rev...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3382859/ https://ncbi.nlm.nih.gov/pubmed/22737618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.18342 |
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