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Neonatal Development of Hepatic UGT1A9: Implications of Pediatric Pharmacokinetics

This article reports on the development of UDP-glucuronosyltransferase 1A9 (UGT1A9) in neonatal and pediatric liver. The substrate 4-methylumbelliferone (4MU) with specific inhibition by niflumic acid was used to define specific UGT1A9 activity. Subsequently, in silico pharmacokinetic (PK) and physi...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Miyagi, Shogo J., Milne, Alison M., Coughtrie, Michael W. H., Collier, Abby C.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382841/
https://ncbi.nlm.nih.gov/pubmed/22492655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.043752
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