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Neonatal Development of Hepatic UGT1A9: Implications of Pediatric Pharmacokinetics
This article reports on the development of UDP-glucuronosyltransferase 1A9 (UGT1A9) in neonatal and pediatric liver. The substrate 4-methylumbelliferone (4MU) with specific inhibition by niflumic acid was used to define specific UGT1A9 activity. Subsequently, in silico pharmacokinetic (PK) and physi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3382841/ https://ncbi.nlm.nih.gov/pubmed/22492655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.043752 |
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