Modulation of mammalian life span by the short isoform of p53

Overexpression of the short isoform of p53 (p44) has unexpectedly uncovered a role for p53 in the regulation of size and life span in the mouse. Hyperactivation of the insulin-like growth factor (IGF) signaling axis by p44 sets in motion a kinase cascade that clamps potentially unimpeded growth thro...

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Detalhes bibliográficos
Main Authors: Maier, Bernhard, Gluba, Wendy, Bernier, Brian, Turner, Terry, Mohammad, Khalid, Guise, Theresa, Sutherland, Ann, Thorner, Michael, Scrable, Heidi
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC338283/
https://ncbi.nlm.nih.gov/pubmed/14871929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1162404
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