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Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK

The transcriptional coactivator PPAR gamma coactivator 1 α (PGC-1α) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1α in humans have been associated with type II diabetes. PGC-1α contains a nega...

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Detalhes bibliográficos
Main Authors: Fan, Melina, Rhee, James, St-Pierre, Julie, Handschin, Christoph, Puigserver, Pere, Lin, Jiandie, Jäeger, Sibylle, Erdjument-Bromage, Hediye, Tempst, Paul, Spiegelman, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC338281/
https://ncbi.nlm.nih.gov/pubmed/14744933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1152204
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