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Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia

Cerebellar ataxia, a devastating neurological disease, may be initiated by hyperexcitability of deep cerebellar nuclei (DCN) secondary to loss of inhibitory input from Purkinje neurons that frequently degenerate in this disease. This mechanism predicts that intrinsic DCN hyperexcitability would caus...

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Publicado no:J Clin Invest
Principais autores: Shakkottai, Vikram G., Chou, Chin-hua, Oddo, Salvatore, Sailer, Claudia A., Knaus, Hans-Günther, Gutman, George A., Barish, Michael E., LaFerla, Frank M., Chandy, K. George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC338266/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966567/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20216
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