Inhibition of CLIC4 Enhances Autophagy and Triggers Mitochondrial and ER Stress-Induced Apoptosis in Human Glioma U251 Cells under Starvation

CLIC4/mtCLIC, a chloride intracellular channel protein, localizes to mitochondria, endoplasmic reticulum (ER), nucleus and cytoplasm, and participates in the apoptotic response to stress. Apoptosis and autophagy, the main types of the programmed cell death, seem interconnected under certain stress c...

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Main Authors: Zhong, Jiateng, Kong, Xiaoxia, Zhang, Hongyu, Yu, Chunyan, Xu, Ye, Kang, Jinsong, Yu, Huimei, Yi, Haowei, Yang, Xiaochun, Sun, Liankun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382619/
https://ncbi.nlm.nih.gov/pubmed/22761775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039378
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