Structural engineering of a phage lysin that targets Gram-negative pathogens

Bacterial pathogens are becoming increasingly resistant to antibiotics. As an alternative therapeutic strategy, phage therapy reagents containing purified viral lysins have been developed against Gram-positive organisms but not against Gram-negative organisms due to the inability of these types of d...

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Autors principals: Lukacik, Petra, Barnard, Travis J., Keller, Paul W., Chaturvedi, Kaveri S., Seddiki, Nadir, Fairman, James W., Noinaj, Nicholas, Kirby, Tara L., Henderson, Jeffrey P., Steven, Alasdair C., Hinnebusch, B. Joseph, Buchanan, Susan K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382549/
https://ncbi.nlm.nih.gov/pubmed/22679291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203472109
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