Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells

Our knowledge of the O-glycoproteome [N-acetylgalactosamine (GalNAc) type] is highly limited. The O-glycoproteome is differentially regulated in cells by dynamic expression of a subset of 20 polypeptide GalNAc-transferases (GalNAc-Ts), and methods to identify important functions of individual GalNAc...

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Autors principals: Schjoldager, Katrine T.-B. G., Vakhrushev, Sergey Y., Kong, Yun, Steentoft, Catharina, Nudelman, Aaron S., Pedersen, Nis B., Wandall, Hans H., Mandel, Ulla, Bennett, Eric P., Levery, Steven B., Clausen, Henrik
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382506/
https://ncbi.nlm.nih.gov/pubmed/22566642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203563109
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