Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire

Idiosyncratic adverse drug reactions are unpredictable, dose-independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve immune mechanisms, and genetic association st...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ostrov, David A., Grant, Barry J., Pompeu, Yuri A., Sidney, John, Harndahl, Mikkel, Southwood, Scott, Oseroff, Carla, Lu, Shun, Jakoncic, Jean, de Oliveira, Cesar Augusto F., Yang, Lun, Mei, Hu, Shi, Leming, Shabanowitz, Jeffrey, English, A. Michelle, Wriston, Amanda, Lucas, Andrew, Phillips, Elizabeth, Mallal, Simon, Grey, Howard M., Sette, Alessandro, Hunt, Donald F., Buus, Soren, Peters, Bjoern
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382472/
https://ncbi.nlm.nih.gov/pubmed/22645359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207934109
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