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Clopidogrel: A Case for Indication-Specific Pharmacogenetics

The CYP2C19*2 loss-of-function allele is associated with reduced generation of active metabolites of clopidogrel. However, meta-analyses have supported or discounted the impact of genotype on adverse cardiovascular outcomes during clopidogrel therapy, depending on studies included in the analysis. H...

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Autors principals: Johnson, JA, Roden, DM, Lesko, LJ, Ashley, E, Klein, TE, Shuldiner, AR
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382015/
https://ncbi.nlm.nih.gov/pubmed/22513313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2012.21
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