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The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation
Natural killer (NK) cells play critical roles defending against tumors and pathogens. We show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to develop NK cells. Developmental stability of immature NK cells constitutively expressing the death ligand TRAIL depended...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381976/ https://ncbi.nlm.nih.gov/pubmed/22261438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.11.016 |
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