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miRNA regulation of macrophage fusion into multinucleated giant cells

Cellular fusion of macrophages into multinucleated giant cells is a distinguishing feature of the granulomatous response to inflammation, infection and foreign bodies (1). We observed a marked increase in fusion of macrophages genetically deficient in Dicer, an enzyme required for canonical miRNA bi...

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Detalhes bibliográficos
Main Authors: Sissons, James R., Peschon, Jacques J., Schmitz, Frank, Suen, Rosa, Gilchrist, Mark, Aderem, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381877/
https://ncbi.nlm.nih.gov/pubmed/22661094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102477
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