Delivery of Quantum Dot-siRNA Nanoplexes in SK-N-SH Cells for BACE1 Gene Silencing and Intracellular Imaging

The fluorescent quantum dots (QDs) delivered small interfering RNAs (siRNAs) targeting β-secretase (BACE1) to achieve high transfection efficiency of siRNAs and reduction of β-amyloid (Aβ) in nerve cells. The CdSe/ZnS QDs with the conjugation of amino-polyethylene glycol (PEG) were synthesized. Nega...

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Detalhes bibliográficos
Main Authors: Li, Shengliang, Liu, Zhonghua, Ji, Fengtao, Xiao, Zijian, Wang, Minjuan, Peng, Yingji, Zhang, Yulin, Liu, Ling, Liang, Zibing, Li, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381642/
https://ncbi.nlm.nih.gov/pubmed/23343930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.11
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