Nanotechnology approach for drug addiction therapy: Gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons

Drug abuse is a worldwide health concern in which addiction involves activation of the dopaminergic signaling pathway in the brain. Here, we introduce a nanotechnology approach that utilizes gold nanorod-DARPP-32 siRNA complexes (nanoplexes) that target this dopaminergic signaling pathway in the bra...

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Detalhes bibliográficos
Main Authors: Bonoiu, Adela C., Mahajan, Supriya D., Ding, Hong, Roy, Indrajit, Yong, Ken-Tye, Kumar, Rajiv, Hu, Rui, Bergey, Earl J., Schwartz, Stanley A., Prasad, Paras N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667003/
https://ncbi.nlm.nih.gov/pubmed/19307583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901715106
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