Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity by Small Molecule GMX1778 Regulates Reactive Oxygen Species (ROS)-mediated Cytotoxicity in a p53- and Nicotinic Acid Phosphoribosyltransferase1 (NAPRT1)-dependent Manner

Cancer cells undergo mitosis more frequently than normal cells and thus have increased metabolic needs, which in turn lead to higher than normal reactive oxygen species (ROS) production. Higher ROS production increases cancer cell dependence on ROS scavenging systems to balance the increased ROS. Se...

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Dettagli Bibliografici
Autori principali: Cerna, David, Li, Hongyun, Flaherty, Siobhan, Takebe, Naoko, Coleman, C. Norman, Yoo, Stephen S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381200/
https://ncbi.nlm.nih.gov/pubmed/22570471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357301
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