Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity by Small Molecule GMX1778 Regulates Reactive Oxygen Species (ROS)-mediated Cytotoxicity in a p53- and Nicotinic Acid Phosphoribosyltransferase1 (NAPRT1)-dependent Manner

Cancer cells undergo mitosis more frequently than normal cells and thus have increased metabolic needs, which in turn lead to higher than normal reactive oxygen species (ROS) production. Higher ROS production increases cancer cell dependence on ROS scavenging systems to balance the increased ROS. Se...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Cerna, David, Li, Hongyun, Flaherty, Siobhan, Takebe, Naoko, Coleman, C. Norman, Yoo, Stephen S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381200/
https://ncbi.nlm.nih.gov/pubmed/22570471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357301
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