Mutation in Cyclophilin B That Causes Hyperelastosis Cutis in American Quarter Horse Does Not Affect Peptidylprolyl cis-trans Isomerase Activity but Shows Altered Cyclophilin B-Protein Interactions and Affects Collagen Folding

The rate-limiting step of folding of the collagen triple helix is catalyzed by cyclophilin B (CypB). The G6R mutation in cyclophilin B found in the American Quarter Horse leads to autosomal recessive hyperelastosis cutis, also known as hereditary equine regional dermal asthenia. The mutant protein s...

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Detalhes bibliográficos
Main Authors: Ishikawa, Yoshihiro, Vranka, Janice A., Boudko, Sergei P., Pokidysheva, Elena, Mizuno, Kazunori, Zientek, Keith, Keene, Douglas R., Rashmir-Raven, Ann M., Nagata, Kazuhiro, Winand, Nena J., Bächinger, Hans Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381186/
https://ncbi.nlm.nih.gov/pubmed/22556420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333336
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