Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells

The platelet activation receptor CLEC-2 plays crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis, although its role in thrombosis/hemostasis remains controversial. An endogenous ligand for CLEC-2, podoplanin, is expressed in lymphatic endothelial cells (LECs). We and oth...

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Main Authors: Osada, Makoto, Inoue, Osamu, Ding, Guo, Shirai, Toshiaki, Ichise, Hirotake, Hirayama, Kazuyoshi, Takano, Katsuhiro, Yatomi, Yutaka, Hirashima, Masanori, Fujii, Hideki, Suzuki-Inoue, Katsue, Ozaki, Yukio
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381185/
https://ncbi.nlm.nih.gov/pubmed/22556408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329987
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