L-Sox5 and Sox6 Proteins Enhance Chondrogenic miR-140 MicroRNA Expression by Strengthening Dimeric Sox9 Activity

Sox9 plays a critical role in early chondrocyte initiation and promotion as well as repression of later maturation. Fellow Sox family members L-Sox5 and Sox6 also function as regulators of cartilage development by boosting Sox9 activation of chondrocyte-specific genes such as Col2a1 and Agc1; howeve...

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Bibliografske podrobnosti
Main Authors: Yamashita, Satoshi, Miyaki, Shigeru, Kato, Yoshio, Yokoyama, Shigetoshi, Sato, Tempei, Barrionuevo, Francisco, Akiyama, Haruhiko, Scherer, Gerd, Takada, Shuji, Asahara, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381182/
https://ncbi.nlm.nih.gov/pubmed/22547066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.343194
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