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Modelling Cell Polarization Driven by Synthetic Spatially Graded Rac Activation

The small GTPase Rac is known to be an important regulator of cell polarization, cytoskeletal reorganization, and motility of mammalian cells. In recent microfluidic experiments, HeLa cells endowed with appropriate constructs were subjected to gradients of the small molecule rapamycin leading to syn...

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Detalhes bibliográficos
Main Authors: Holmes, William R., Lin, Benjamin, Levchenko, Andre, Edelstein-Keshet, Leah
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380869/
https://ncbi.nlm.nih.gov/pubmed/22737059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002366
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