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A simple assay for 3-deoxy-d-manno-octulosonate cytidylyltransferase (KdsB) and its use as a pathway screen

This paper describes the adaptation of a simple colorimetric assay for inorganic pyrophosphate to the enzyme 3-deoxy-d-manno-octulosonate cytidylyltransferase(CMP-KDO synthetase, KdsB, E.C. 2.7.7.38), a key enzyme in the biosynthesis of lipopolysaccharide (LPS) in Gram-negative organisms. This assay...

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Main Authors: Yi, Li, Velasquez, Melvin S., Holler, Tod P., Woodard, Ronald W.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380378/
https://ncbi.nlm.nih.gov/pubmed/21669179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2011.05.022
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