A potential therapeutic target for FLT3-ITD AML: PIM1 Kinase

Patients with acute myeloid leukemia (AML) and a FLT3 internal tandem duplication (ITD) mutation have a poor prognosis, and FLT3 inhibitors are now under clinical investigation. PIM1, a serine/threonine kinase, is up-regulated in FLT3-ITD AML and may be involved in FLT3-mediated leukemogenesis. We e...

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Main Authors: Fathi, Amir T., Arowojolu, Omotayo, Swinnen, Ian, Sato, Takashi, Rajkhowa, Trivikram, Small, Donald, Marmsater, Fredrik, Robinson, John E., Gross, Stefan David, Martinson, Matthew, Allen, Shelley, Kallan, Nicholas C., Levis, Mark
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380375/
https://ncbi.nlm.nih.gov/pubmed/21802138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2011.07.011
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