A potential therapeutic target for FLT3-ITD AML: PIM1 Kinase

Patients with acute myeloid leukemia (AML) and a FLT3 internal tandem duplication (ITD) mutation have a poor prognosis, and FLT3 inhibitors are now under clinical investigation. PIM1, a serine/threonine kinase, is up-regulated in FLT3-ITD AML and may be involved in FLT3-mediated leukemogenesis. We e...

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Detaylı Bibliyografya
Asıl Yazarlar: Fathi, Amir T., Arowojolu, Omotayo, Swinnen, Ian, Sato, Takashi, Rajkhowa, Trivikram, Small, Donald, Marmsater, Fredrik, Robinson, John E., Gross, Stefan David, Martinson, Matthew, Allen, Shelley, Kallan, Nicholas C., Levis, Mark
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380375/
https://ncbi.nlm.nih.gov/pubmed/21802138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2011.07.011
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