Maternal deprivation in rats is associated with corticotropin releasing hormone (CRH) promoter hypomethylation and enhances CRH transcriptional responses to stress in adulthood

Exposure to stress during early development causes long-lasting alterations in behavior and hypothalamic pituitary adrenal (HPA) axis activity, including increased expression of corticotropin releasing hormone (CRH). To determine whether early life stress causes epigenetic changes in the CRH promote...

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Autori principali: Chen, Jun, Evans, Andrew N., Liu, Ying, Honda, Masaru, Saavedra, Juan M., Aguilera, Greti
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380160/
https://ncbi.nlm.nih.gov/pubmed/22375940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2826.2012.02306.x
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