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Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresia

CD8 T-lymphocytes are effector cells of cholangiocyte injury in human and in rhesus rotavirus (RRV) induced experimental biliary atresia (BA). Here, we hypothesize that neonatal deficiency in CD25(+)CD4(+) regulatory T cells (Tregs) leads to aberrant activation of hepatic T-lymphocytes in BA. We fou...

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Main Authors: Lages, Celine S., Simmons, Julia, Chougnet, Claire A., Miethke, Alexander G.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380144/
https://ncbi.nlm.nih.gov/pubmed/22334397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25662
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