EGFR and HER2 Genomic Gain in Recurrent Non-small Cell Lung Cancer After Surgery: Impact on Outcome to Treatment with Gefitinib and Association with EGFR and KRAS Mutations in a Japanese Cohort

BACKGROUND: Sensitivity to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) and frequency of activation mutations in EGFR is lower in Caucasian than Asian non small-cell lung cancer (NSCLC) patients. Increased EGFR gene copy numbers evaluated by fluorescence in situ hybridiz...

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Main Authors: Varella-Garcia, Marileila, Mitsudomi, Tetsuya, Yatabe, Yashushi, Kosaka, Takayuki, Nakajima, Eiji, Xavier, Ana Carolina, Skokan, Margaret, Zeng, Chan, Franklin, Wilbur A., Bunn, Paul A., Hirsch, Fred R.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379811/
https://ncbi.nlm.nih.gov/pubmed/19247083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31819667a3
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