Inhibition of the Catalytic Function of Activation-Induced Cytidine Deaminase (AID) Promotes Apoptosis of Germinal Center B cells

OBJECTIVE: This study is to determine if functional suppression of the catalytic domain of activation-induced cytidine deaminase (AID) can suppress the hyper-reactive germinal center responses in BXD2 mice. METHODS: A transgenic (Tg) BXD2 mouse expressing a dominant negative (DN) form of AID (Aicda-...

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Autores principales: Hsu, Hui-Chen, Yang, PingAr, Wu, Qi, Wang, John H., Job, Godwin, Guentert, Tanja, Li, Jun, Stockard, Cecil R., Le, Thuc vy, Chaplin, David D., Grizzle, William E., Mountz, John D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379710/
https://ncbi.nlm.nih.gov/pubmed/21305519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30257
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