Nonlinearity between action potential alternans and restitution, which both predict ventricular arrhythmic properties in Scn5a(+/−) and wild-type murine hearts

Electrocardiographic QT- and T-wave alternans, presaging ventricular arrhythmia, reflects compromised adaptation of action potential (AP) duration (APD) to altered heart rate, classically attributed to incomplete Na(v)1.5 channel recovery prior to subsequent stimulation. The restitution hypothesis s...

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Main Authors: Matthews, Gareth D. K., Guzadhur, Laila, Grace, Andrew, Huang, Christopher L-H.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2012
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379158/
https://ncbi.nlm.nih.gov/pubmed/22461438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00039.2012
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