Proteomic analysis of secretagogue-stimulated neutrophils implicates a role for actin and actin-interacting proteins in Rac2-mediated granule exocytosis

BACKGROUND: Neutrophils are abundant leukocytes that play a primary role in defence against pathogens. Neutrophils enter sites of infection where they eliminate pathogens via phagocytosis and the release of antimicrobial mediators via degranulation. Rho GTPases, particularly Rac2, play a key role in...

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Hauptverfasser: Eitzen, Gary, Lo, Andrea N, Mitchell, Troy, Kim, John D, Chao, Danny V, Lacy, Paige
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379032/
https://ncbi.nlm.nih.gov/pubmed/22081935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5956-9-70
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