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Biogenesis of mammalian microRNAs by a non-canonical processing pathway
Canonical microRNA biogenesis requires the Microprocessor components, Drosha and DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The Microprocessor is not required for processing of some miRNAs, including mirtrons, in which spliceosome-excised introns are direct Dicer substrates....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378869/ https://ncbi.nlm.nih.gov/pubmed/22270084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks026 |
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