α-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system

The source of Parkinson disease-linked α-synuclein (aSyn) in human cerebrospinal fluid (CSF) remains unknown. We decided to measure the concentration of aSyn and its gradient in human CSF specimens and compared it with serum to explore its origin. We correlated aSyn concentrations in CSF versus seru...

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Hlavní autoři: Mollenhauer, Brit, Trautmann, Ellen, Otte, Birgit, Ng, Juliana, Spreer, Annette, Lange, Peter, Sixel-Döring, Friederike, Hakimi, Mansoureh, VonSattel, Jean-Paul, Nussbaum, Robert, Trenkwalder, Claudia, Schlossmacher, Michael G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Vienna 2012
Témata:
Basic Neurosciences, Genetics and Immunology - Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378837/
https://ncbi.nlm.nih.gov/pubmed/22426833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00702-012-0784-0
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