Lack of a p21(waf1/cip)-Dependent G1/S Checkpoint in Neural Stem and Progenitor Cells After DNA Damage In Vivo

The cyclin-dependent kinase inhibitor p21(waf1/cip) mediates the p53-dependent G1/S checkpoint, which is generally considered to be a critical requirement to maintain genomic stability after DNA damage. We used staggered 5-ethynyl-2′deoxyuridine/5-bromo-2′-deoxyuridine double-labeling in vivo to inv...

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Bibliographische Detailangaben
Hauptverfasser: Roque, Telma, Haton, Céline, Etienne, Olivier, Chicheportiche, Alexandra, Rousseau, Laure, Martin, Ludovic, Mouthon, Marc-André, Boussin, François D
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley Subscription Services, Inc., A Wiley Company 2012
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Original Research: Tissue-Specific Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378718/
https://ncbi.nlm.nih.gov/pubmed/22162343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1010
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