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Phosphoinositide-3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt’s Lymphoma cells to BH3-mimetics
Burkitt’s lymphoma (BL), driven by translocation and over-expression of the c-MYC gene, is an aggressive, highly proliferative lymphoma and novel therapeutic strategies are required to overcome drug resistance following conventional treatments. The importance of the pro-survival BCL-2 family member...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378513/ https://ncbi.nlm.nih.gov/pubmed/22241218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0394 |
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