Induced chromosome deletions cause hypersociability and other features of Williams–Beuren syndrome in mice

The neurodevelopmental disorder Williams–Beuren syndrome is caused by spontaneous ∼1.5 Mb deletions comprising 25 genes on human chromosome 7q11.23. To functionally dissect the deletion and identify dosage-sensitive genes, we created two half-deletions of the conserved syntenic region on mouse chrom...

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Hlavní autoři: Li, Hong Hua, Roy, Madhuri, Kuscuoglu, Unsal, Spencer, Corinne M, Halm, Birgit, Harrison, Katharine C, Bayle, Joseph H, Splendore, Alessandra, Ding, Feng, Meltzer, Leslie A, Wright, Elena, Paylor, Richard, Deisseroth, Karl, Francke, Uta
Médium: Artigo
Jazyk:Inglês
Vydáno: WILEY-VCH Verlag 2009
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378107/
https://ncbi.nlm.nih.gov/pubmed/20049703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900003
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