Induced chromosome deletions cause hypersociability and other features of Williams–Beuren syndrome in mice

The neurodevelopmental disorder Williams–Beuren syndrome is caused by spontaneous ∼1.5 Mb deletions comprising 25 genes on human chromosome 7q11.23. To functionally dissect the deletion and identify dosage-sensitive genes, we created two half-deletions of the conserved syntenic region on mouse chrom...

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Detalhes bibliográficos
Main Authors: Li, Hong Hua, Roy, Madhuri, Kuscuoglu, Unsal, Spencer, Corinne M, Halm, Birgit, Harrison, Katharine C, Bayle, Joseph H, Splendore, Alessandra, Ding, Feng, Meltzer, Leslie A, Wright, Elena, Paylor, Richard, Deisseroth, Karl, Francke, Uta
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378107/
https://ncbi.nlm.nih.gov/pubmed/20049703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900003
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