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Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma()
Pten, one of the most common tumor suppressors in human cancers, antagonizes signaling by the PI3K pathway. Mice with thymocyte-specific deletion of Pten rapidly developed peripheral lymphomas and autoimmunity, which may have been due to failed negative selection of thymocytes or from dysregulation...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378038/ https://ncbi.nlm.nih.gov/pubmed/22611241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102116 |
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